A paradigm changer of aesthetic and regenerative fat grafting

E4S Enzyme

GMP grade collagenase GMP Grade E4zyme AS is an aseptically filled, lyophilized mixture of 60% purified class I (C1) and 40% purified class II (C2) collagenase from Clostridium histolyticum pre-mixed with neutral protease from Bacillus polymyxa. CIzyme AS can be used for isolating adipose derived stromal cells from human lipoaspirate.

SKU: e4senzyme
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GMP Grade E4zyme AS is an aseptically filled, lyophilized mixture of 60% purified class I (C1) and 40% purified class II (C2) collagenase from Clostridium histolyticum pre-mixed with neutral protease from Bacillus polymyxa. CIzyme AS can be used for isolating adipose derived stromal cells from human lipoaspirate.

  • Manufactured for superior lot-to-lot enzyme consistency for improved performance consistency
  • Optimal enzyme activity (28-42 Wünsch Units) and neutral protease activity (220,000 – 340,000 NP units) per vial to dissociate approximately 100 grams of human adipose tissue.
  • Low contaminating endotoxin levels (<25 EU/OD)
  • White lyophilized cake under vacuum in amber bottle sealed with butyl rubber stopper
  • Stable for at least 2 years when stored at 2-8 ℃
  • Lyophilized in a buffer containing calcium to ensure enzyme stability during initial reconstitution.
Appearance

White lyophilized cake

Total Wünsch Activity

30 – 40 Units/Vial

Total Neutral Protease Activity

220,000 – 350,000 Units/Vial

Storage

2-8°C

Shelf Life

2 Years